Hans Briem: search on Z-Library

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1

Neue Erkenntnisse über molekulare Wirkungsmechanismen von Arzneistoffen

Prof. Dr. Hans-Dieter Höltje, Anita Batzenschlager, Hans Briem, Jörg Brüggmann

Journal:

Pharmazie in unserer Zeit

Year:

1991

Language:

german

File:

PDF, 1.89 MB

german, 1991

2

Facing the Challenges of Structure-Based Target Prediction by Inverse Virtual Screening

Schomburg, Karen T., Bietz, Stefan, Briem, Hans, Henzler, Angela M., Urbaczek, Sascha, Rarey, Matthias

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 4.73 MB

english, 2014

3

Ultrafast de

Marcus Gastreich, Markus Lilienthal, Hans Briem, Holger Claussen

Journal:

Journal of Computer-Aided Molecular Design

Year:

2006

Language:

english

File:

PDF, 837 KB

english, 2006

4

Cover Picture: The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer (ChemMedChem 7/2

Lücking, Ulrich, Jautelat, Rolf, Krüger, Martin, Brumby, Thomas, Lienau, Philip, Schäfer, Martina, Briem, Hans, Schulze, Julia, Hillisch, Alexander, Reichel, Andreas, Wengner, Antje Margret, Siemeiste

Journal:

Year:

2013

Language:

english

File:

PDF, 688 KB

english, 2013

5

Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer

Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Boemer, Ulf, Schäfer,

Journal:

Year:

2017

Language:

english

File:

PDF, 1.86 MB

english, 2017

6

Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells towards Taxanes, ATR and PARP Inhibitors in vitro and in vivo

Siemeister, Gerhard, Mengel, Anne, Fernández-Montalván, Amaury E., Bone, Wilhelm, Schröder, Jens, Zitzmann-Kolbe, Sabine, Briem, Hans, Prechtl, Stefan, Holton, Simon J., Mönning, Ursula, von Ahsen, Ol

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 9.72 MB

english, 2018

7

Efficient Multi-Objective Molecular Optimization in a Continuous Latent Space

Winter, Robin, Montanari, Floriane, Steffen, Andreas, Briem, Hans, Noe, Frank, Clevert, Djork-Arné

Journal:

Chemical Science

Year:

2019

Language:

english

File:

PDF, 5.38 MB

english, 2019

8

Substantial improvements in large-scale redocking and screening using the novel HYDE scoring function

Nadine Schneider, Sally Hindle, Gudrun Lange, Robert Klein, Jürgen Albrecht, Hans Briem, Kristin Beyer, Holger Claußen, Marcus Gastreich, Christian Lemmen, Matthias Rarey

Journal:

Journal of Computer-Aided Molecular Design

Year:

2012

Language:

english

File:

PDF, 1.52 MB

english, 2012

9

Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models

Luecking, Ulrich, Wortmann, Lars, Wengner, Antje Margret, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Boemer, Ulf, Denner, Karsten, Schaefer, Martina, Koppitz, Marcus, Eis, Knut

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 732 KB

2020

10

Parvovirus B19 infection and autoimmune hepatitis in a child with sickle cell anemia

Uwe Kordes, Reinhard Schneppenheim, Andrea Briem-Richter, Stefanie Scherpe, Hans-Jörg Schäfer

Journal:

Pediatric Blood & Cancer

Year:

2011

Language:

english

File:

PDF, 101 KB

english, 2011

11

An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer − against all odds?

Follmann, Markus, Briem, Hans, Steinmeyer, Andreas, Hillisch, Alexander, Schmitt, Monika H., Haning, Helmut, Meier, Heinrich

Journal:

Drug Discovery Today

Year:

2018

Language:

english

File:

PDF, 487 KB

english, 2018

12

Bandwidth allocation mechanism for LAN/MAN interworking with an ATM network

Wolfgang Schödl, Uwe Briem, Hans Kröner, Thomas Theimer

Journal:

Computer Communications

Year:

1993

Language:

english

File:

PDF, 614 KB

english, 1993

13

Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions

Wen, Bo, Wu, Hao, Loh, Yuin-Han, Briem, Eirikur, Daley, George Q, Feinberg, Andrew P

Journal:

Year:

2012

Language:

english

File:

PDF, 730 KB

english, 2012

14

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmann, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, J

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 1.86 MB

2019

15

Front Cover: Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C (ChemMedChem 10/2020)

Mortier, JÃ©rÃ©mie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut

Journal:

Year:

2020

File:

PDF, 999 KB

2020

16

The V368i mutation in Twinkle does not segregate with adPEO

Joaquín Arenas, Egill Briem, Henrik Dahl, Wendy Hutchison, Sharon Lewis, Miguel A. Martin, Hans Spelbrink, Valeria Tiranti, Howy Jacobs, Massimo Zeviani

Journal:

Annals of Neurology

Year:

2003

Language:

english

File:

PDF, 43 KB

english, 2003

17

Multiple-Conformation and Protonation-State Representation in 4D-QSAR: The Neurokinin-1 Receptor System

Vedani, Angelo, Briem, Hans, Dobler, Max, Dollinger, Horst, McMasters, Daniel R.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 292 KB

english, 2000

18

The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor ( R )- S -Cyclopropyl- S -(4-{[4-{[(1 R ,2 R )-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer

Lücking, Ulrich, Jautelat, Rolf, Krüger, Martin, Brumby, Thomas, Lienau, Philip, Schäfer, Martina, Briem, Hans, Schulze, Julia, Hillisch, Alexander, Reichel, Andreas, Wengner, Antje Margret, Siemeiste

Journal:

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

19

Cognition and character traits as determinants of young children's behaviour in traffic situations

Bengtsson, Valdimar Briem, Hans

Journal:

International Journal of Behavioral Development

Year:

2000

Language:

english

File:

PDF, 360 KB

english, 2000

20

Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C

Mortier, JÃ©rÃ©mie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut

Journal:

Year:

2020

File:

PDF, 1.29 MB

2020

21

From the Insoluble Dye Indirubin towards Highly Active, Soluble CDK2-Inhibitors

Rolf Jautelat, Thomas Brumby, Martina Schäfer, Hans Briem, Gerhard Eisenbrand, Stefan Schwahn, Martin Krüger, Ulrich Lücking, Olaf Prien, Gerhard Siemeister

Journal:

Year:

2005

Language:

english

File:

PDF, 348 KB

english, 2005

22

Theoretical Determination of the Putative Receptor-bound Conformations of 5-HT2 Receptor Agonists

Hans-Dieter Höltje, Hans Briem

Journal:

Molecular Informatics

Year:

1991

Language:

english

File:

PDF, 605 KB

english, 1991

23

Binding Kinetics Survey of the Drugged Kinome

Georgi, Victoria, Schiele, Felix, Berger, Benedict-Tilman, Steffen, Andreas, Marin Zapata, Paula A., Briem, Hans, Menz, Stephan, Preuße, Cornelia, Vasta, James D., Robers, Matthew B., Brands, Michael,

Journal:

Journal of the American Chemical Society

Year:

2018

Language:

english

File:

PDF, 3.32 MB

english, 2018

24

Classifying “Kinase Inhibitor-Likeness” by Using Machine-Learning Methods

Hans Briem, Judith Günther

Journal:

Year:

2005

Language:

english

File:

PDF, 235 KB

english, 2005

25

Ermüdungsverzögerung durch Vitamin B1

Hans Joseph Briem

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1939

Language:

german

File:

PDF, 329 KB

german, 1939

26

Molecular Similarity Based on DOCK-Generated Fingerprints

Briem, Hans, Kuntz, Irwin D.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 278 KB

english, 1996

27

Macrocyclic Aminopyrimidines as Multitarget CDK and VEGF-R Inhibitors with Potent Antiproliferative Activities

Ulrich Lücking, Gerhard Siemeister, Martina Schäfer, Hans Briem, Martin Krüger, Philip Lienau, Rolf Jautelat

Journal:

Year:

2007

Language:

english

File:

PDF, 422 KB

english, 2007

28

Discovery of BAY-985 a highly selective TBK1/Ikkε inhibitor

Lefranc, Julien, Schulze, Volker K., Hillig, Roman Christian, Briem, Hans, Prinz, Florian, Mengel, Anne, Heinrich, Tobias, Bálint, József, Rengachari, Srinivasan, Irlbacher, Horst, Stöckigt, Detlef, B

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 1.05 MB

2019

29

Synthesis of a new dipeptide template, its X-ray structure, and modeling studies on its conformational features

FRANZ ESSER, ALAIN CARPY, HANS BRIEM, HERBERT KÖPPEN, KARL-HEINZ POOK

Journal:

Chemical Biology & Drug Design

Year:

1995

Language:

english

File:

PDF, 499 KB

english, 1995

30

Mining High-Throughput Screening Data of Combinatorial Libraries: Development of a Filter to Distinguish Hits from Nonhits.

Andreas Teckentrup, Hans Briem, Johann Gasteiger

Journal:

Year:

2004

File:

PDF, 52 KB

2004

31

Synthesis of cyclic dipeptide templates, their incorporation into peptides and studies on their conformational and biological properties

GEERT ASCHE, HORST KUNZ, HERBERT NAR, HERBERT KÖPPEN, HANS BRIEM, KARL-HEINZ POOK, PETER W. SCHILLER, NGA N. CHUNG, CAROLE LEMIEUX, FRANZ ESSER

Journal:

Chemical Biology & Drug Design

Year:

1998

Language:

english

File:

PDF, 1.87 MB

english, 1998

32

In vitro and in silico affinity fingerprints: Finding similarities beyond structural classes

Hans Briem, Uta F. Lessel

Journal:

Perspectives in Drug Discovery and Design

Year:

2000

Language:

english

File:

PDF, 156 KB

english, 2000

33

Computational Macrocyclization: From de novo Macrocycle Generation to Binding Affinity Estimation

Wagner, Vincent, Jantz, Linda, Briem, Hans, Sommer, Kai, Rarey, Matthias, Christ, Clara

Journal:

Year:

2017

Language:

english

File:

PDF, 1.32 MB

english, 2017

34

Future carbon dioxide emissions in the global material flow of primary aluminium

Hans-Günter Schwarz, Sebastian Briem, Petra Zapp

Journal:

Year:

2001

Language:

english

File:

PDF, 313 KB

english, 2001

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